Thermo Fisher Scientific GPCR GPR120 Polyclonal Antibody
Thermo Fisher Scientific의 GPCR GPR120 폴리클로날 항체로 인간, 마우스, 랫트 반응성을 보유. Western blot, ELISA, IP에 적합하며, C-epitope 합성 펩타이드로 면역화된 Rabbit IgG 항체. 연구용으로 높은 특이성과 안정적 액상 형태 제공.
- 카탈로그번호
- FFAR4-412AP
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | C-epitope synthetic peptide taken within amino acid region 220–300 on human FFAR4 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
An EST for GPR120 has been isolated from a human colon cancer library.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist.
All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors.
Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell and continues to drive pharmacological research for new drug candidates.
Two blockbuster drugs developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough), which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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