Thermo Fisher Scientific CCR2 Recombinant Superclonal Antibody

Applications

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Sheep, Bovine, and Goat.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They comprise multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.
These antibodies recognize multiple epitope sites on the target, providing higher detection sensitivity for low-abundance targets. Each lot maintains consistent composition by using recombinant technology, eliminating biological variability found in traditional polyclonal antibody production.

Note: Formerly called “Recombinant Polyclonal Antibody,” now rebranded as “Recombinant Superclonal™ Antibody.” The physical product and performance remain unchanged.

Target Information

CCR2 is a chemokine receptor that regulates monocyte/macrophage trafficking and is upregulated in response to inflammation.
Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), produced by endothelial cells, smooth muscle cells, and macrophages.
Activation of monocytes by MCP-1 may mediate tissue infiltration in atherosclerosis and inflammatory disorders such as rheumatoid arthritis, alveolitis, and tumor infiltration.
CCR2 is expressed in various tissues including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessels. Increased expression has been observed in CD3+ lymphocytes in rheumatoid arthritis.

ESTs have been isolated from liver/spleen and prostate libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.