Thermo Fisher Scientific DDHD1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL
• Publications: [References not provided]

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:500–1:1,000
• Publications: [References not provided]

Product Specifications

Product Specific Information

Immunogen sequence:
NTAMMREAAR KIEERHFSNH ATHVEFLPVE WRSKLTLDGD TVDSITPDKV RGLRDMLNSS AMDIMYYTSP LYRDELVKGL QQELNRLYSL FCSRNPD

Antigen sequence identity (orthologs):

• Mouse: 98%
• Rat: 98%

Target Information

The DDHD1 gene belongs to the intracellular phospholipase A1 family. The encoded protein preferentially hydrolyzes phosphatidic acid and is mainly cytosolic with partial mitochondrial localization. It is implicated in regulating mitochondrial dynamics:

• Overexpression leads to mitochondrial fragmentation
• Depletion results in mitochondrial tubule elongation

In male mice, gene deletion causes fertility defects due to disrupted mitochondrial organization during spermiogenesis.
In humans, DDHD1 mutations are linked to hereditary spastic paraplegia (HSP), also known as Strumpell-Lorrain disease or familial spastic paraparesis (FSP), characterized by progressive lower limb weakness and spasticity.
Alternative splicing produces multiple transcript variants encoding different isoforms.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.