Thermo Fisher Scientific CD3 Monoclonal Antibody (UCHT1), Biotin, eBioscience
인간 CD3e를 인식하는 UCHT1 클론 단일클론 항체로, 비오틴 결합 형태입니다. Flow cytometry에 최적화되어 있으며, T세포 활성화 및 증식 연구에 적합합니다. 0.5 mg/mL 농도의 액상 제품으로 4°C 암소 보관이 필요합니다.
- 카탈로그번호
- 13-0038-82
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific CD3 Monoclonal Antibody (UCHT1), Biotin, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 3 publications |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 1 µg/test | View 26 publications |
| Functional Assay | - | View 1 publication |
| Miscellaneous (PubMed) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UCHT1 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_466323 |
Available Formats
- Unconjugated
- Alexa Fluor 532, 561, 660, 700
- APC, APC-eFluor 780
- Brilliant UV, Violet, NovaFluor, PE series
- FITC, eFluor, Super Bright conjugates
- Functional Grade
- Custom conjugation available upon request
Product Specific Information
The UCHT1 monoclonal antibody reacts with human CD3e, a 20 kDa subunit of the TCR complex. The epsilon chain, along with gamma and delta subunits, is essential for proper assembly and surface expression of the TCR complex. CD3 is expressed by thymocytes and mature T cells. Crosslinking via UCHT1 triggers intracellular signaling leading to activation and proliferation.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Flow cytometry of normal human peripheral blood cells (≤ 1 µg/test)
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
The CD3 complex transduces antigen-recognition signals into T cells and regulates TCR surface expression. CD3 subunits (gamma, delta, epsilon, zeta) are members of the immunoglobulin superfamily encoded on chromosome 11. They associate with signal transduction molecules via a tyrosine-based motif. CD3 is expressed on most T lymphocytes and thymocytes but not on B or NK cells. Defects in CD3 genes can lead to immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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