Thermo Fisher Scientific IgA (Immunoglobulin Alpha Heavy Chain) (B-Cell Marker) Recombinant Rabbit Monoclonal Antibody (IGHA/3877R)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Target Information

Constant region of immunoglobulin heavy chains.
Immunoglobulins (antibodies) are membrane-bound or secreted glycoproteins produced by B lymphocytes.
In humoral immunity, membrane-bound immunoglobulins act as receptors that trigger clonal expansion and differentiation into plasma cells upon antigen binding.
Secreted immunoglobulins mediate antigen elimination during the effector phase of humoral immunity.
Each immunoglobulin has two antigen-binding sites formed by the variable domains of heavy and light chains.
The variable domains undergo V-(D)-J rearrangement and somatic hypermutation for affinity maturation.
Ig alpha (IgA) is the major immunoglobulin class in body secretions.
[UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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