Thermo Fisher Scientific IgA (Immunoglobulin Alpha Heavy Chain) (B-Cell Marker) Recombinant Rabbit Monoclonal Antibody (IGHA/3877R)
IgA(B-Cell Marker) 항체로 인간 IgA1 및 IgA2 중쇄를 인식하며, IHC(P) 및 면역전기영동에 사용 가능. HEK293 발현 시스템의 재조합 토끼 단일클론 항체로, 높은 특이성과 안정성 보유. 단백질 A/G 정제, 4°C 보관, 연구용 전용.
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Thermo Fisher Scientific IgA (Immunoglobulin Alpha Heavy Chain) (B-Cell Marker) Recombinant Rabbit Monoclonal Antibody (IGHA/3877R)
Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
- Immunoelectrophoresis (IE): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | IGHA/3877R |
| Immunogen | Recombinant full-length human IGHA1 and IGHA2 proteins |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Stability: Antibody is stable for 24 months.
- Positive Control: Daudi, 293T, Raji, or hPBL cells; human tonsil or spleen.
- Cellular Localization: Cytoplasm, cell surface, and secreted.
- Specificity Comments:
- Specific to heavy chain of IgA with minimal cross-reaction to other immunoglobulin heavy chains.
- Reactive with both IgA1 and IgA2 subclasses.
- Recognizes CH3 domain of alpha chain of IgA molecules.
- IgA is the main protein of the mucosal immune system, generated by B-cells in gut-associated lymphoid tissues.
- Exists mainly as dimers, but can also form polymers or monomers containing a joining (J) chain for mucosal transport.
- Restricted expression of a single heavy chain class can indicate clonality and malignancy in lymphoid infiltrates.
Target Information
Human IgA (immunoglobulin A) is an antibody produced by the immune system in response to antigens. It is abundant in mucosal secretions such as saliva, tears, and breast milk, providing defense against pathogens at mucosal surfaces. IgA binds to antigens, prevents tissue invasion, activates complement, and promotes phagocytosis.
Research applications include studying immune responses and developing diagnostic and therapeutic tools for infectious diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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