Thermo Fisher Scientific IgA (Immunoglobulin Alpha Heavy Chain) (B-Cell Marker) Recombinant Rabbit Monoclonal Antibody (IGHA/3877R)

Thermo Fisher Scientific IgA (Immunoglobulin Alpha Heavy Chain) (B-Cell Marker) Recombinant Rabbit Monoclonal Antibody (IGHA/3877R)

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
• Immunoelectrophoresis (IE): Assay-dependent

Product Specifications

Product Specific Information

• Stability: Antibody is stable for 24 months.
• Positive Control: Daudi, 293T, Raji, or hPBL cells; human tonsil or spleen.
• Cellular Localization: Cytoplasm, cell surface, and secreted.
• Specificity Comments:
  • Specific to heavy chain of IgA with minimal cross-reaction to other immunoglobulin heavy chains.
  • Reactive with both IgA1 and IgA2 subclasses.
  • Recognizes CH3 domain of alpha chain of IgA molecules.
  • IgA is the main protein of the mucosal immune system, generated by B-cells in gut-associated lymphoid tissues.
  • Exists mainly as dimers, but can also form polymers or monomers containing a joining (J) chain for mucosal transport.
  • Restricted expression of a single heavy chain class can indicate clonality and malignancy in lymphoid infiltrates.

Target Information

Human IgA (immunoglobulin A) is an antibody produced by the immune system in response to antigens. It is abundant in mucosal secretions such as saliva, tears, and breast milk, providing defense against pathogens at mucosal surfaces. IgA binds to antigens, prevents tissue invasion, activates complement, and promotes phagocytosis.
Research applications include studying immune responses and developing diagnostic and therapeutic tools for infectious diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.