Thermo Fisher Scientific SIGLEC8 Polyclonal Antibody
SIGLEC8 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, ELISA, Inhibition Assay에 사용 가능하며, 고순도의 Affinity Chromatography 정제 제품입니다. PBS/glycerol buffer로 안정화되어 장기 보관이 용이합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| ELISA | 1 µg/mL | - |
| Inhibition Assays (IA) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 17–363 of human Siglec-8 (NP_0552572) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.23 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804543 |
Product Specific Information
Immunogen sequence:
MEGDRQYGDG YLLQVQELVT VQEGLCVHVP CSFSYPQDGW TDSDPVHGYW FRAGDRPYQD APVATNNPDR EVQAETQGRF QLLGDIWSND CSLSIRDARK RDKGSYFFRL ERGSMKWSYK SQLNYKTKQL SVFVTALTHR PDILILGTLE SGHSRNLTCS VPWACKQGTP PMISWIGASV SSPGPTTARS SVLTLTPKPQ DHGTSLTCQV TLPGTGVTTT STVRLDVSYP PWNLTMTVFQ GDATASTALG NGSSLSVLEG QSLRLVCAVN SNPPARLSWT RGSLTLCPSR SSNPGLLELP RVHVRDEGEF TCRAQNAQGS QHISLSLSLQ NEGTGTSRPV SQVTLAA
Positive Samples: HL-60, 293T, Mouse liver, Rat blood
Cellular Location: Membrane, Single-pass type I membrane protein
Target Information
SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to α2,3-linked sialic acid and also binds to α2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC8 is expressed specifically on eosinophils. The protein contains one copy of a cytoplasmic motif referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM), which is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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