Thermo Fisher Scientific Calcineurin B homologous protein 2/HCC Antigen 520 Monoclonal Antibody (CPTC-CHP2-1)
CHP2 단백질을 표적하는 Mouse monoclonal 항체로, Western blot, IHC, ICC 등 다양한 응용에 사용 가능. Human 시료에 반응하며, Protein A/G 정제, PBS buffer에 보존. Tumor-associated antigen 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CPTC-CHP2-1 |
| Immunogen | Recombinant human full-length CHP2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
CHP2 (Calcineurin B homologous protein 2), also known as Hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein containing four EF-hand domains that play a potential role in transmembrane Na⁺/H⁺ exchange. By binding to and activating NHE-1, CHP2 increases intracellular pH and protects cells from serum deprivation-induced death. Although not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells, while knockdown of CHP2 mRNA in HepG2 cells inhibits proliferation. Like calcineurin B, CHP2 can bind to and stimulate the phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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