Thermo Fisher Scientific Calcineurin B homologous protein 2/HCC Antigen 520 Monoclonal Antibody (CPTC-CHP2-1)

Applications and Tested Dilution

Product Specifications

Target Information

CHP2 (Calcineurin B homologous protein 2), also known as Hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein containing four EF-hand domains that play a potential role in transmembrane Na⁺/H⁺ exchange. By binding to and activating NHE-1, CHP2 increases intracellular pH and protects cells from serum deprivation-induced death. Although not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells, while knockdown of CHP2 mRNA in HepG2 cells inhibits proliferation. Like calcineurin B, CHP2 can bind to and stimulate the phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.