Thermo Fisher Scientific SDHB (Succinate Dehydrogenase B) (Pheochromocytoma Marker) Monoclonal Antibody (SDHB/2126)
SDHB 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체. Western blot 및 면역조직화학(IHC)에 적합. 인간 시료 반응성, 마우스 IgG1 아이소타입. 단백질 A/G 정제, PBS 용액 형태로 제공. 연구용으로만 사용 가능.
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- 6390-MSM1-P1ABX
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1.0 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SDHB/2126 |
| Immunogen | Recombinant human SDHB fragment around aa 165–273 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Complex II of the respiratory chain is involved in the oxidation of succinate and transfers electrons from FADH to CoQ. The complex consists of four nuclear-encoded subunits localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters that may form the enzyme’s iron-sulfur centers. Mutations in this gene are associated with paragangliomas and pheochromocytoma, indicating a link between mitochondrial dysfunction and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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