Thermo Fisher Scientific Amyloid Fibrils Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recognizes generic epitopes common to many amyloid fibrils and fibrillar oligomers, but not prefibrillar oligomers or natively folded proteins.
• Expected to detect Mouse and Rat based on species homology.
• A 1:1,000 dilution of PA5-77843 was sufficient for detection of amyloid fibrils on PVDF membranes using colorimetric dot blot analysis with Goat anti-rabbit IgG:HRP as the secondary antibody.

Target Information

Amyloid monomeric proteins can oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease-related proteins can form through partial misfolding or denaturation.
Degenerative diseases associated with misfolded protein accumulation include:

• Alzheimer’s disease (amyloid-beta peptide plaques, tau neurofibrillary tangles)
• Parkinson’s disease (alpha-synuclein deposition in Lewy bodies)
• Huntington’s disease (polyglutamine-containing aggregates)

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.