Thermo Fisher Scientific Aconitase 1 Polyclonal Antibody
Thermo Fisher Scientific의 Aconitase 1 Polyclonal Antibody는 인간 ACO1 단백질을 인식하는 토끼 유래 IgG 항체입니다. Western blot 및 IHC(P) 실험에 적합하며, 세포 내 철 항상성 연구에 활용됩니다. 고순도 항원 친화 크로마토그래피 정제 제품으로 안정적 보관이 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human Aconitase 1 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2735425 |
Product Specific Information
- Positive Control: A431, HeLa, HepG2
- Predicted Reactivity: Mouse (87%), Rat (86%), Rabbit (90%), Rhesus Monkey (99%), Bovine (89%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Aconitase 1 (ACO1), also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein that binds to iron-responsive elements (IREs).
It plays a central role in cellular iron homeostasis and exhibits aconitase enzymatic activity.
IREs are stem-loop structures found in the 5′ UTR of ferritin mRNA and the 3′ UTR of transferrin receptor mRNA.
Iron-induced binding to IRE regulates ferritin translation and transferrin receptor mRNA stability, thus maintaining iron balance within cells.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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