Thermo Fisher Scientific Phospho-NMDAR2B (Ser1303) Polyclonal Antibody

Thermo Fisher Scientific Phospho-NMDAR2B (Ser1303) Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

A suggested positive control for Western blot is mouse brain cells.

Target Information

NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) are involved in long-term potentiation, an activity-dependent increase in synaptic transmission efficiency that underlies memory and learning.
NMDAR2B plays a role in neuronal development and has been implicated in central nervous system disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death.
Overexpression of the NR2B subunit is associated with enhanced learning and memory, while reduced expression is observed in aged, memory-impaired animals. Phosphorylation at Tyr1472 may increase NMDAR expression at synapses, contributing to synaptic plasticity.
NMDAR2B forms a heterotrimeric complex with NR1, NR2, and NR3 subunits. Dysfunction is linked to epileptic encephalopathy and autosomal dominant mental retardation.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.