Thermo Fisher Scientific Phospho-NMDAR2B (Tyr1474) Polyclonal Antibody
Phospho-NMDAR2B (Tyr1474) rabbit polyclonal antibody for ICC/IF applications. Reacts with human, mouse, and rat. Affinity-purified, unconjugated, liquid form. Useful for studying NMDA receptor signaling and synaptic plasticity.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:200
- Suggested positive control: HeLa cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of Tyr1474 (H-V-Y(p)-E-K) derived from Human NMDAR2B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554199 |
Product Specific Information
- Suggested positive control for Western blot: A431 cells
- Suggested positive control for ICC/IF: HeLa cells
Target Information
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. These receptors are involved in long-term potentiation, an activity-dependent increase in synaptic transmission efficiency, which is essential for memory and learning. NMDAR2B plays a key role in neuronal development and is implicated in neurological disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death. Phosphorylation at Tyr1472 may enhance NMDAR expression at the synapse, contributing to synaptic plasticity. Overexpression of NR2B is associated with improved learning and memory, while reduced expression is seen in aged, memory-impaired animals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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