Thermo Fisher Scientific ALKBH4 Polyclonal Antibody
ALKBH4 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 ICC/IF에 사용 가능하며, 인간 및 마우스 시료에 반응. 액상 형태로 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
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- PA5100872
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ALKBH4 (Accession Q9NXW9), corresponding to amino acid residues G140–V190 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2850369 |
Product Specific Information
Antibody detects endogenous levels of total ALKBH4.
Target Information
Dioxygenase that mediates demethylation of actin monomethylated at Lys-84 (K84me1), thereby acting as a regulator of actomyosin processes (PubMed:23673617).
Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617).
In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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