Thermo Fisher Scientific HRH4 Polyclonal Antibody

Thermo Fisher Scientific HRH4 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Positive Control: HL-60 MF (unboiled).
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

The Histamine H4 receptor has been reported in human peripheral blood leukocytes, bone marrow, colon, liver, lung, small intestine, spleen, testis, thymus, tonsil, and trachea. Unlike the mouse H4 receptor, the human gene is not detected in the brain.
G-protein Coupled Receptors (GPCRs) represent one of the largest families of signaling molecules, sharing a structural motif of seven membrane-spanning helices. They exist in active and inactive forms, with activating ligands inducing conformational changes leading to G-protein signaling and downstream effects.
Studies have revealed complex mechanisms for negative regulation of GPCRs, which are critical to cellular physiology and pharmacological research. Notable GPCR-targeted drugs include Zyprexa (Eli Lilly) and Claritin (Schering-Plough).

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.