Thermo Fisher Scientific MMP13 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MMP13 for IHC(P) applications. Recognizes C-terminal peptide of MMP13. High specificity and affinity purified. Supplied in liquid form, 1 mg/mL, with PBS and 0.1% sodium azide. For research use only.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from C-terminus of human MMP13 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551309 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gorilla (100%)
- Gibbon, Monkey, Marmoset (94%)
- Dog, Elephant (89%)
- Sheep, Bovine, Panda, Horse, Pig (83%)
Target Information
MMP13 (collagenase 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN.
It cleaves triple helical collagens (types I, II, and III), showing highest activity with soluble type II collagen.
MMP13 can degrade collagen types IV, XIV, and X, and is involved in wound healing, tissue remodeling, cartilage degradation, bone development, and ossification.
Mutations in MMP13 are associated with spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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