Thermo Fisher Scientific MRGD Polyclonal Antibody
Human MRGPRD 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS에 0.1% sodium azide를 포함한 액상 형태. 통증 조절 관련 연구용으로 적합.
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Applications
- Immunohistochemistry (Paraffin) [IHC (P)]: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from 4th cytoplasmic domain of human MRGPRD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551311 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human: 100%
- Gorilla: 94%
- Gibbon: 89%
Target Information
May regulate nociceptor function and/or development, including the sensation or modulation of pain.
Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evokes Ca(2+) influx in cells expressing the receptor.
Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting coupling with G-proteins G(q) and G(i).
Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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