Thermo Fisher Scientific PD L1 (CD274) Monoclonal Antibody (OTI9A5)
인간 PD-L1(CD274)을 인식하는 Mouse IgG2b 단일클론 항체로, Western blot 및 Flow cytometry에 적합. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도 유지. 종양 면역회피 연구 및 PD-1/PD-L1 상호작용 분석에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9A5 |
| Immunogen | Full length human recombinant protein of human CD274 (NP_054862) produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional round of desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a B7 family member that binds to the programmed death receptor 1 (PD-1), negatively regulating T-cell receptor (TCR) signaling. PD-L1 engagement reduces TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant in many murine and human cancers and is up-regulated upon IFN-gamma stimulation, suggesting its role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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