Thermo Fisher Scientific TNFR1 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Keep as a concentrated solution.
• Positive Control: A549, A549 membrane fraction extract.
• Centrifuge briefly prior to opening the vial.

Target Information

TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily and is one of the major TNF-alpha receptors. TNFR1 is involved in cytokine-mediated signaling, positive regulation of the NF-κB pathway, angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 can be released into circulation as soluble TNFR1 (sTNFR1).
In humans, the TNFR1 gene is located on chromosome 12. Proteins such as BAG4/SODD, TRADD, and TRAF2 interact with TNFR1 and regulate its signal transduction. Germline mutations in TNFR1’s extracellular domain are associated with autosomal dominant periodic fever syndrome, where impaired receptor clearance is implicated in disease mechanisms.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.