Thermo Fisher Scientific CD100 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (83%), Rat (83%).
• Positive Control: 293T, Jurkat, Raji.
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development.
CD100 (also known as Semaphorin 4D), a 150 kDa homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro.
CD100 modifies CD40-CD40L B cell signaling by augmenting B cell aggregation and survival and downregulating CD23 expression.
CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling.
CD100 is expressed on resting and PHA-stimulated T cells. The protein is weakly expressed on NK cells, EBV-transformed B cells, monocytes, and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.