Thermo Fisher Scientific Phospho-LRRK2 (Ser935) Recombinant Rabbit Monoclonal Antibody (3H8L19)
Phospho-LRRK2 (Ser935) 항체로 인간 LRRK2 단백질의 인산화 상태를 검출. Western blot, IHC, ICC/IF에 사용 가능. 재조합 토끼 단일클론으로 높은 특이성과 일관성 제공. 단기 4°C, 장기 -20°C 보관.
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Thermo Fisher Scientific Phospho-LRRK2 (Ser935) Recombinant Rabbit Monoclonal Antibody (3H8L19)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:10–1:50 |
| Immunocytochemistry (ICC/IF) | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3H8L19 |
| Immunogen | Phosphopeptide corresponding to amino acids 930–940 of human LRRK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2532367 |
Product Specific Information
- Predicted to react with non-human primate, mouse, and rat based on sequence homology.
- On non-reducing gel: intact IgG appears as ~150 kDa band; under reducing conditions, ~25 kDa light chain and ~50 kDa heavy chain bands observed.
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems.
- Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
LRRK2 is a multidomain protein containing kinase, GTPase, and leucine-rich repeat (LRR) domains. Mutations in LRRK2 are linked to Parkinson’s disease. The protein includes ankyrin repeat, LRR, kinase, DFG-like motif, RAS, GTPase, MLK-like, and WD40 domains. It is mainly cytoplasmic but also associates with the mitochondrial outer membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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