Thermo Fisher Scientific PRAS40 Recombinant Rabbit Monoclonal Antibody (4H14L8)
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
701075 | - | Thermo Fisher Scientific 701075 PRAS40 Recombinant Rabbit Monoclonal Antibody (4H14L8) 100 ug pk | 재고문의 | pk | 0원 | - | 0원 |
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Applications
Tested Dilution
Publications
Western Blot (WB)
1:100-1:1,000
View 1 publication 1 publication
Immunocytochemistry (ICC/IF)
1:100-1:500
View 1 publication 1 publication
Product Specifications
Published species
Human
Host/Isotype
Rabbit / IgG
Class
Recombinant Monoclonal
Type
Antibody
Clone
4H14L8
Immunogen
Recombinant protein corresponding to amino acids 2-256 of human PRAS40.
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2532373
Product Specific Information
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
The Akt signaling pathway contributes to the regulation of apoptosis after a variety of cell death signals. AKT1S1, also known as PRAS40, is a proline-rich substrate of the kinase AKT1 and is thought to play a role in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia. AKT1S1 is also a substrate and potential regulator of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Treatment with the insulin-like growth factor-1 (IGF1) can induce the phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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