Thermo Fisher Scientific Glucagon Polyclonal Antibody
Thermo Fisher Scientific의 Glucagon Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. 고순도 Rabbit IgG 폴리클로날 항체로, 글루카곤 관련 세포 및 종양 마커 연구에 유용합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 21–180 of human Pro-glucagon (NP_0020451) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.58 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804644 |
Product Specific Information
Immunogen Sequence:
RSLQDTEEKS RSFSASQADP LSDPDQMNED KRHSQGTFTS DYSKYLDSRR AQDFVQWLMN TKRNRNNIAK RHDEFERHAE GTFTSDVSSY LEGQAAKEFI AWLVKGRGRR DFPEEVAIVE ELGRRHADGS FSDEMNTILD NLAARDFINW LIQTKITDRK
Target Information
Glucagon is a 29-residue polypeptide hormone (MW 3482), produced in the pancreas. A related hormone, enteroglucagon (or oxyntomodulin), produced in the mucosa of the small and large intestine, consists of the 29 amino acid sequence of pancreatic glucagon extended by 8 additional residues at the C-terminus.
Biological activities of pancreatic glucagon include:
- Glycogenolysis
- Lipolysis
- Gluconeogenesis
- Ketogenesis
These are antagonistic to insulin action, leading to increased blood glucose levels.
Immunocytochemical studies have revealed the presence of pancreatic glucagon inside the A (alpha) cells, which constitute 15–20% of the islet cell population, located preferentially at the periphery of human pancreatic islets.
Pathological manifestations of glucagon-type peptide residues are associated with tumors or glucagonomas, as no states of glucagon-cell deficiency or hyperplasia have been identified.
Glucagon-specific antibodies are useful as:
- Cell and tumor markers via immunohistochemical techniques
- Analytical tools for hormone quantification
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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