Thermo Fisher Scientific PPBP Monoclonal Antibody, PeproTech

Applications

Product Specifications

Product Specific Information

AA Sequence of recombinant protein:
AELRCMCIKT TSGIHPKNIQ SLEVIGKGTH CNQVEVIATL KDGRKICLDP DAPRIKKIVQ KKLAGDESAD

Preparation:
Produced in mice immunized with highly pure Recombinant Human NAP-2 (CXCL7).
Anti-Human NAP-2 (CXCL7)-specific antibody was purified from cell culture by Protein G affinity chromatography.

Target Information

Members of the α-chemokine subfamily of inducible, secreted, pro-inflammatory cytokines contain a similar motif, in which the first two cysteine residues are separated by a single residue (Cys-X-Cys), and are also chemotactic for neutrophils.
The platelet basic protein (PBP), a member of the α-chemokine family, resides in the α-granules of platelets and is released upon their activation. Proteolytic cleavage of the amino terminus of PBP leads to the generation of several peptides, including mature PBP, connective tissue-activating peptide III (CTAP III, also designated low affinity platelet factor IV (LA-PF4)), β-thromboglobulin (β-TG), and neutrophil-activating peptide 2 (NAP-2).
PBP and its N-truncated derivatives mediate inflammation and wound healing. Specifically, NAP-2 activates chemotaxis and degranulation in neutrophils during inflammation. The gene encoding human PBP maps to chromosome 4q12–q13.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.