Thermo Fisher Scientific CD34 (Hematopoietic Stem Cell and Endothelial Marker) Monoclonal Antibody (SPM610)
CD34 단백질을 인식하는 단클론 항체로, 조혈모세포 및 내피세포 표지 연구에 적합. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용 가능. 인간 및 랫트 반응성. 단백질 A/G 정제, 4°C 보관.
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD34 (Hematopoietic Stem Cell and Endothelial Marker) Monoclonal Antibody (SPM610)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 2–4 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM610 |
| Immunogen | Recombinant full-length human HPCA1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD34 is a highly glycosylated monomeric surface protein with a molecular weight range of 111–115 kDa, expressed on various stem cell populations. It serves as a marker for hematopoietic stem cells, though its expression is reversible. CD34 may function as a receptor involved in receptor-mediated endocytosis, regulating adhesion, differentiation, and proliferation of hematopoietic and progenitor cells. It is also considered an adhesion molecule facilitating stem cell attachment to the bone marrow extracellular matrix or stromal cells. Additionally, CD34 may act as a scaffold for lineage-specific glycans, enabling interactions with lectins on stromal or marrow cells. The intracellular domain of CD34 can be phosphorylated by protein kinase C, suggesting a role in signal transduction. CD34 dysfunction has been associated with diseases such as dermatofibrosarcoma and neurofibroma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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