Thermo Fisher Scientific uPAR Monoclonal Antibody (A6E8)
Human uPAR(CD87)을 인식하는 Mouse IgG1 단클론 항체로 Western blot에 적합합니다. Recombinant human uPA receptor(aa 51-250/335)를 면역원으로 사용하였으며, 2 mg/mL 농도의 액상 형태로 제공됩니다. 세포막 및 분비 위치 단백질 검출에 활용됩니다.
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Thermo Fisher Scientific uPAR Monoclonal Antibody (A6E8)
Applications
- Western Blot (WB)
Tested Dilution: 1:500
Publications: [참고 문헌 없음]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A6E8 |
| Immunogen | Recombinant protein within human uPA Receptor aa 51-250/335 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091326 |
Product Specific Information
- Positive Control: U937 cell lysate, U937 cell lysate treated with 200 nM PMA for 72 hours
- Predicted Band Size: 36 kDa
- Subcellular Location: Cell membrane, invadopodium membrane; Secreted
Target Information
The urokinase-type plasminogen activator receptor (uPAR, CD87) is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in normal and pathological processes.
Human PLAUR cDNA encodes 335 amino acids including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. It produces a highly glycosylated protein (~50 kDa) anchored to the plasma membrane via glycosyl-phosphatidylinositol linkage.
PLAUR associates with SELL and β2 integrins in neutrophil membranes, mediating calcium mobilization.
UPAR mRNA levels correlate with invasive potential and disease progression in endometrial carcinomas, serving as a prognostic marker for advanced cancer.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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