Thermo Fisher Scientific uPAR Monoclonal Antibody (A6E7)
인간 uPAR(CD87)을 인식하는 Mouse IgG1 단클론 항체로, Western blot에 최적화됨. 비결합형 액상 형태이며 2 mg/mL 농도, Protein G로 정제됨. 세포막 및 분비 위치 단백질 검출에 적합하며 연구용으로 사용.
- 카탈로그번호
- MA550590
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific uPAR Monoclonal Antibody (A6E7)
Applications
Western Blot (WB)
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A6E7 |
| Immunogen | Recombinant protein within human uPA Receptor aa 51–250/335 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_3091325 |
Product Specific Information
- Positive control: U937 cell lysate, U937 cell lysate treated with 200 nM PMA for 72 hours
- Predicted band size: 36 kDa
- Subcellular Location: Cell membrane, invadopodium membrane; Secreted
Target Information
The urokinase-type plasminogen activator receptor (uPAR) regulates cell-surface plasminogen activation and is involved in various physiological and pathological processes.
Human PLAUR cDNA encodes 335 amino acids, including a 22-residue signal peptide and hydrophobic C-terminal region. The protein (~50 kDa) is glycosylated and anchored to the plasma membrane via glycosyl-phosphatidylinositol linkage.
PLAUR (UPAR) interacts with SELL and beta-2 integrins in neutrophil membranes, influencing calcium mobilization.
UPAR mRNA levels are significantly elevated in advanced endometrial carcinomas, correlating with disease progression, recurrence, and mortality.
UPAR serves as a potential prognostic marker for advanced endometrial cancer.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.