Thermo Fisher Scientific IDH1 Recombinant Rabbit Monoclonal Antibody (10H39L6)

Applications

• Western Blot (WB)
  Tested Dilution: 1:200–1:500

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Pig, Dog, and Rat.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened for optimal candidates.

Advantages:

• Superior specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to large rabbit immune repertoire

Target Information

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes are divided into NAD(+)-dependent and NADP(+)-dependent subclasses.

Five isocitrate dehydrogenases have been reported:

1. Three NAD(+)-dependent forms localized to the mitochondrial matrix
2. Two NADP(+)-dependent forms, one mitochondrial and one cytosolic

The IDH1 gene encodes the NADP(+)-dependent isocitrate dehydrogenase found in cytoplasm and peroxisomes. It includes a PTS-1 peroxisomal targeting sequence and contributes to NADPH regeneration for peroxisomal reduction reactions and cytoplasmic NADPH production.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.