Thermo Fisher Scientific HPa1 Monoclonal Antibody (HP3/17)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:4,000

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Immunohistochemistry (Paraffin) (IHC (P))

1:40

-

Immunocytochemistry (ICC/IF)

-

View 1 publication 1 publication

Product Specifications

Published species

Not Applicable

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

HP3/17

Immunogen

Polypeptide from the 50 kDa subunit of heparanase

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3.57 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2120721

Product Specific Information

Purity is ~98% by SDS PAGE.

Mouse anti Human Heparanase-1 antibody, clone HP3/17 recognizes heparanase-1, also know as HPA1, an endo-beta-D-glucuronidase that degrades heparan sulfate proteoglycans (HSPGs) in the extracellular matrix through cleavage of the heparan sulfate side chains.

Target Information

Stem cells offer a therapeutic promise for many diseases. In the case of diabetes, stem cells offer the promise that beta cells may be generated ex vivo for the possible transplantation and cure of Type I diabetes (Couri CE, et al. ). For this to happen, stem cells will need to be isolated and expanded, they will need to be differentiated toward the beta cell lineage, and the differentiated cell progeny used for transplantation may need to be isolated from complex cell mixtures following differentiation. Appropriate markers targeting cell surface molecules on developing and mature pancreatic cells will be required for such research.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.