Thermo Fisher Scientific Apolipoprotein J Monoclonal Antibody (3R3/2)
Apolipoprotein J 단백질을 표적하는 마우스 단클론 항체로, Western blot, IHC, Flow cytometry, ELISA 등 다양한 연구 응용에 사용 가능. Protein A로 정제된 액상 형태이며, 1 mg/mL 농도. 인간 시료 반응성이 높고, clusterin 단백질 인식에 적합.
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Thermo Fisher Scientific Apolipoprotein J Monoclonal Antibody (3R3/2)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
| Miscellaneous PubMed | - |
Publication: View 1 publication
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3R3/2 |
| Immunogen | Glomerular basement membrane from a post-mortem kidney |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | BBS, pH 8.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_930015 |
Product Specific Information
- A suggested positive control for immunohistochemical applications is kidney from post streptococcal glomerulonephritis patients.
- Mouse anti-Human clusterin antibody, clone 3R3/2 recognizes clusterin, an ubiquitously expressed protein composed of two 40 kDa chains (alpha and beta) covalently joined by disulfide bonds.
Target Information
Isoform 1 functions as an extracellular chaperone that prevents aggregation of nonnative proteins and stress-induced aggregation of blood plasma proteins. It inhibits amyloid fibril formation by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants (in vitro).
Clusterin does not require ATP and maintains partially unfolded proteins for subsequent refolding by other chaperones such as HSPA8/HSC70. It binds to cell surface receptors, triggering internalization and degradation of the chaperone-client complex.
Secreted isoform 1 protects cells against apoptosis and complement-mediated cytolysis, while intracellular isoforms interact with ubiquitin and SCF E3 ubiquitin ligase complexes to promote proteasomal degradation of target proteins.
Additionally, clusterin modulates NF-kappa-B transcriptional activity, with nuclear isoforms promoting apoptosis and mitochondrial isoforms inhibiting BAX-dependent cytochrome c release.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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