
Thermo Fisher Scientific Phospho-TOP2A (Ser1469) Polyclonal Antibody
Phospho-TOP2A (Ser1469) 폴리클로날 항체로 인간 및 생쥐 시료에서 인산화된 TOP2A 검출에 적합. Western Blot 및 IHC(Paraffin)에 사용 가능. 고순도 정제된 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TOP2A (Accession P11388), corresponding to amino acid residues around phosphorylated Ser1469 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816147 |
Product Specific Information
Antibody detects endogenous levels of TOP2A only when phosphorylated at Ser1469.
Target Information
Topo II alpha plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis.
It is reported to be a sensitive and specific marker of late S-, G2 and M-phases in transformed and developmentally regulated normal cells.
Topo II alpha is also implicated in drug resistance of tumor cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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