Thermo Fisher Scientific Phospho-TNK1 (Tyr277) Polyclonal Antibody
TNK1 단백질의 Tyr277 인산화 형태를 특이적으로 인식하는 rabbit polyclonal 항체. Western blot 및 IHC(P)에서 사용 가능. 인간, 생쥐, 랫트 반응성. 1 mg/mL 액상 형태로 제공되며 -20°C 보관.
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- PA5104671
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TNK1 (Accession Q13470), corresponding to amino acid residues around phosphorylated Tyr277 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816146 |
Product Specific Information
This antibody detects endogenous levels of TNK1 only when phosphorylated at Tyr277.
Target Information
TNK1 (tyrosine kinase, non-receptor 1) belongs to the tyrosine protein kinase family and is an important regulator of intracellular signal transduction pathways mediating cellular proliferation, survival, and development. TNK1 is highly expressed in fetal tissues and at lower levels in certain adult tissues. It may function broadly in fetal development and selectively in adult tissues. TNK1 negatively regulates the Ras-Raf1-MAPK pathway, and knockout mice develop spontaneous tumors, suggesting a tumor suppressor role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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