Thermo Fisher Scientific Periostin Recombinant Rabbit Monoclonal Antibody (14F2)
인간 Periostin을 인식하는 재조합 토끼 단클론 항체로, IHC, Flow Cytometry, ELISA에 사용 가능. 고순도 친화 크로마토그래피 정제, 비결합형 액상 형태. 골형성 및 암 관련 연구용으로 적합하며 안정적 저장 가능.
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Thermo Fisher Scientific Periostin Recombinant Rabbit Monoclonal Antibody (14F2)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:200 |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 14F2 |
| Immunogen | A synthesized peptide derived from Human POSTN |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092542 |
Target Information
Periostin (PN), also known as osteoblast-specific factor 2 (OSF-2), is a disulfide-linked protein originally isolated as an osteoblast-specific factor. It is a secreted protein that binds heparin and functions as a ligand for α(V)β(3) and α(V)β(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading, and attachment.
Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues, but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Its expression is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGF-β1). The protein contains a signal sequence, a cysteine-rich domain, four repeated fasciclin-like domains, and a C-terminal domain.
Additional Information
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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