Thermo Fisher Scientific PATZ1 Polyclonal Antibody
PATZ1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 ELISA에 적합하며, 인간, 마우스, 랫트 시료에 반응. 고순도 Affinity Chromatography로 정제된 액상 형태, 안정적 PBS/glycerol buffer에 보존.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 250–350 of human PATZ1 (NP_0551382) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804278 |
Product Specific Information
- Immunogen sequence: PFPSVASSAP PLTGKRGRGR PRKANLLDSM FGSPGGLREA GILPCGLCGK VFTDANRLRQ HEAQHGVTSL QLGYIDLPPP RLGENGLPIS EDPDGPRKRS R
- Positive Samples: HT-29, HeLa, MCF7, HL-60, HepG2, Mouse kidney, Mouse spleen, Mouse lung, Rat kidney
- Cellular Location: Nucleus
Target Information
The PATZ1 protein contains an A-T hook DNA binding motif that interacts with other DNA-binding structures, playing a key role in chromatin modeling and transcription regulation. Its POZ domain mediates protein-protein interactions essential for transcriptional repression, while zinc-finger regions form the DNA-binding domain. PATZ1 acts as a transcriptional repressor. In small round cell sarcoma, PATZ1 is fused to EWS through an inversion on chromosome 22q, forming a chimeric protein (t(1;22)(p36.1;q12)) that combines the transactivation domain of EWS with the zinc-finger domain of PATZ1. Four alternatively spliced transcript variants are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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