Thermo Fisher Scientific SNX6 Polyclonal Antibody
SNX6 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 ELISA에 적합하며, 사람·생쥐·랫트 반응성. 액상형, 0.78 mg/mL 농도, -20°C 보관. 세포 내 SNX6 위치 및 TGF-β 수용체 상호작용 연구에 활용 가능.
- 카탈로그번호
- PA587586
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–290 of human SNX6 (NP_0670723) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.78 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804270 |
Product Specific Information
Immunogen sequence:
MTKEEFTKMK QELEAEYLAI FKKTVAMHEV FLCRVAAHPI LRRDLNFHVF LEYNQDLSVR GKNKKEKLED FFKNMVKSAD GVIVSGVKDV DDFFEHERTF LLEYHNRVKD ASAKSDRMTR SHKSAADDYN RIGSSLYALG TQDSTDICKF FLKVSELFDK TRKIEARVSA DEDLKLSDLL KYYLRESQAA KDLLYRRSRS LVDYENANKA LDKARAKNKD VLQAETSQQL CCQKFEKISE SAKQELIDFK TRRVAAFRKN LVELAELELK HAKGNLQLLQ NCLAVLNGDT
Positive Samples:
HepG2, DU145, BT-474, Mouse kidney, Mouse lung, Mouse thymus, Mouse pancreas, Rat kidney
Cellular Location:
Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Early endosome, Early endosome membrane, Nucleus, Peripheral membrane protein
Target Information
SNX6 interacts with members of the transforming growth factor-beta (TGF-β) family of receptor serine-threonine kinases. These receptors include:
- Type II receptors: Bind ligand and recruit type I receptors for signal transduction. SNX6 interacts strongly with ActRIIB and moderately with wild type and kinase-defective mutants of TbetaRII.
- Type I receptors: SNX6 interacts only with inactivated TbetaRI.
SNXs 1–4 also interact with TGF-β receptor family, showing distinct receptor preferences. SNX6 behaves similarly to other SNX proteins in its interactions with receptor tyrosine kinases and forms heteromeric complexes with SNX1, SNX2, SNX4, and SNX6, suggesting oligomeric complex formation in vivo.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-87586_SNX6_Q9UNH7-1_Rabbit.svg, PA5-87586_SNX6_Q9UNH7-1_Rabbit_PDP.jpeg)
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