Thermo Fisher Scientific DDR2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 290-400 of human DDR2 (NP_0010147961) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DDR2,uniProtId:Q16832-1,ncbiNodeId:9606,antigenRange:290-400,antigenLength:855,antigenImageFileName:PA5-87602_DDR2_Q16832-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87602_DDR2_Q16832-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.2 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804281

Product Specific Information

Immunogen sequence: NMFAKGVKIF KEVQCYFRSE ASEWEPNAIS FPLVLDDVNP SARFVTVPLH HRMASAIKCQ YHFADTWMMF SEITFQSDAA MYNNSEALPT SPMAPTTYDP MLKVDDSNTR I; Positive Samples: HeLa, A375, HT-1080, Mouse lung, Mouse heart, Mouse kidney, Rat lung; Cellular Location: Cell membrane, Single-pass type I membrane protein

Target Information

DDR2 is a member of a subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. DDR1 and DDR2 have been shown to be potently inhibited by Gleevec. DDR2 required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.