Thermo Fisher Scientific SHIP1 Monoclonal Antibody (J.571.5)
SHIP1 단백질을 인식하는 Rabbit monoclonal antibody(J.571.5)로, Western blot, ICC/IF, Flow cytometry, IP에 사용 가능. Human 시료에 반응하며, Affinity chromatography로 정제된 액상 항체. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:200 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | J.571.5 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Pro1135 of human SHIP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10982340 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene belongs to the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains.
Expression of this protein is restricted to hematopoietic cells, where its relocation from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation.
At the plasma membrane, the protein hydrolyzes the 5′ phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways.
Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Alternate transcriptional splice variants encoding different isoforms have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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