Thermo Fisher Scientific NUMB Monoclonal Antibody (S.925.4)
NUMB 단백질을 인식하는 Rabbit Monoclonal Antibody (Clone S.925.4). Western blot, ICC/IF, Flow cytometry, IP에 사용 가능. 고순도 친화 크로마토그래피 정제 및 액상 형태로 제공. 신경세포 분화 및 내포 관련 연구에 적합.
- 카탈로그번호
- MA514897
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| Flow Cytometry (Flow) | 1:200 | - |
| Immunoprecipitation (IP) | 1:50 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S.925.4 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Phe482 of human Numb protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 88 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10985378 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca²⁺ channel (VGCC) inhibitor or by Ca²⁺ chelator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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