Thermo Fisher Scientific STEAP3 Polyclonal Antibody
인간 STEAP3 단백질을 인식하는 토끼 폴리클로날 항체. Western blot에 적합하며 HepG2 세포 추출물로 검증됨. 철 및 구리 환원 관련 연구에 유용. 항원 친화 크로마토그래피로 정제된 액상 시약.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–258 of Human STEAP3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.79 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548150 |
Product Specific Information
- Recommended positive control: HepG2 cytoplasm extract
- Predicted reactivity: Mouse (89%), Rat (87%), Bovine (86%)
- Store product as a concentrated solution. Centrifuge briefly before opening the vial.
Target Information
The six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to other STEAP family members (STEAP2 and STEAP4), STEAP3 promotes both iron and copper reduction. It is highly expressed in hematopoietic tissues and colocalizes with the transferrin endosome. Overexpression of STEAP3 stimulates iron reduction; mice lacking STEAP3 are deficient in erythroid ferrireductase activity, indicating that STEAP3 is an endosomal ferrireductase required for transferrin-dependent iron uptake in erythroid cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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