Thermo Fisher Scientific ERBB3 Monoclonal Antibody (OTI1A6), TrueMAB
ERBB3 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI1A6). Western blot 및 Flow cytometry에 사용 가능. Human 시료 반응성. Lyophilized 형태로 제공되며, PBS buffer에 8% trehalose 포함. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Flow Cytometry (Flow) | 1:25–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A6 |
| Immunogen | Full length human recombinant protein of human ERBB3 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family.
ErbB3 is over-expressed in various tumors including prostate, bladder, breast, stomach, pancreas, and colon.
Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.
The ErbB3 gene is located on chromosome 12q13 and encodes a transmembrane receptor tyrosine kinase.
Alternative splicing results in multiple isoforms, including a secreted variant that modulates the activity of the membrane-bound form.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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