Thermo Fisher Scientific MEF2C Monoclonal Antibody (CL0368)
인간 MEF2C 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC/IF에 사용 가능. 단백질 A로 정제된 액상 형태이며, PBS/glycerol buffer에 보존. 심장, 신경, 혈관 발달 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 2–10 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL0368 |
| Immunogen | Recombinant protein corresponding to Human MEF2C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2786988 |
Product Specific Information
Immunogen sequence:
PPNFEMPVSI PVSSHNSLVY SNPVSSLGNP NLLPLAHPSL QRNSMSPGVT HRPPSAGNTG GLMGGDLTSG AGTSAGNGYG NPRNSPGLLV SPGNLNKNMQ AKSPPPMNLG MNNRKPDLRV LIPPGSKNTM PSVNQRINN
Target Information
MEF2C is a transcription activator that binds specifically to the MEF2 element present in regulatory regions of many muscle-specific genes. It controls cardiac morphogenesis and myogenesis and is involved in vascular development. MEF2C plays an essential role in hippocampal-dependent learning and memory by regulating synaptic transmission and neuronal development. It is crucial for megakaryocyte and platelet development, bone marrow B lymphopoiesis, and B-cell survival and proliferation. MEF2C also contributes to neurogenesis and cortical architecture development. Isoform 3 and 4, lacking the repressor domain, are more active than isoform 1 and 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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