Thermo Fisher Scientific ATM Polyclonal Antibody
ATM 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 ELISA에 적합. 인간, 마우스, 랫트 반응성. Affinity Chromatography로 정제된 액상 항체이며, PBS/glycerol buffer에 보관. DNA 손상 복구 및 세포주기 조절 연구에 유용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 2320–2566 of ATM (NP_000042.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.03 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914200 |
Product Specific Information
- Positive test controls: 293T
- Localization: Cytoplasmic vesicle, Nucleus
Immunogen sequence:
DASCAANNPS LKLTYTECLR VCGNWLAETC LENPAVIMQT YLEKAVEVAG NYDGESSDEL RNGKMKAFLS LARFSDTQYQ RIENYMKSSE FENKQALLKR AKEEVGLLRE HKIQTNRYTV KVQRELELDE LALRALKEDR KRFLCKAVEN YINCLLSGEE HDMWVFRLCS LWLENSGVSE VNGMMKRDGM KIPTYKFLPL MYQLAARMGT KMMGGLGFHE VLNNLISRIS MDHPHHTLFI ILALANA
Target Information
Ataxia-telangiectasia Mutated (ATM) belongs to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein kinase that phosphorylates several substrates involved in cell-cycle regulation, including P53, Mdm2, BRCA1, and SMC1.
ATM plays a key role in repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens.
Its C-terminal region shares homology with phosphatidylinositol 3-kinases (PI3 kinases).
ATM is autophosphorylated and upregulated upon exposure to ionizing radiation, mediating DNA damage response pathways including cell cycle arrest and apoptosis regulation.
ATM also interacts with Nbs1 and Chk2 in the E2F1 pathway, linking it to apoptosis mechanisms.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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