Thermo Fisher Scientific ATM Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive test controls: 293T
• Localization: Cytoplasmic vesicle, Nucleus

Immunogen sequence:
DASCAANNPS LKLTYTECLR VCGNWLAETC LENPAVIMQT YLEKAVEVAG NYDGESSDEL RNGKMKAFLS LARFSDTQYQ RIENYMKSSE FENKQALLKR AKEEVGLLRE HKIQTNRYTV KVQRELELDE LALRALKEDR KRFLCKAVEN YINCLLSGEE HDMWVFRLCS LWLENSGVSE VNGMMKRDGM KIPTYKFLPL MYQLAARMGT KMMGGLGFHE VLNNLISRIS MDHPHHTLFI ILALANA

Target Information

Ataxia-telangiectasia Mutated (ATM) belongs to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.

The ATM gene encodes a protein kinase that phosphorylates several substrates involved in cell-cycle regulation, including P53, Mdm2, BRCA1, and SMC1.
ATM plays a key role in repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens.
Its C-terminal region shares homology with phosphatidylinositol 3-kinases (PI3 kinases).
ATM is autophosphorylated and upregulated upon exposure to ionizing radiation, mediating DNA damage response pathways including cell cycle arrest and apoptosis regulation.

ATM also interacts with Nbs1 and Chk2 in the E2F1 pathway, linking it to apoptosis mechanisms.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.