Thermo Fisher Scientific ZHX2 Polyclonal Antibody
ZHX2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC(P), ELISA에 사용 가능. Human, Mouse, Rat 반응성. Affinity Chromatography로 정제되었으며, PBS/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 488–837 of human ZHX2 (NP_055758.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.33 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914198 |
Product Specific Information
- Positive test controls include: U-251MG, 293T, Raji, LO2, Mouse brain.
- Immunogen sequence:
SDHRYRCQRG IVHITSESLA KDQLAIAASR HGRTYHAYPD FAPQKFKEKT QGQVKILEDS FLKSSFPTQA ELDRLRVETK LSRREIDSWF SERRKLRDSM EQAVLDSMGS GKKGQDVGAP NGALSRLDQL SGAQLTSSLP SPSPAIAKSQ EQVHLLRSTF ARTQWPTPQE YDQLAAKTGL VRTEIVRWFK ENRCLLKTGT VKWMEQYQHQ PMADDHGYDA VARKATKPMA ESPKNGGDVV PQYYKDPKKL CEEDLEKLVT RVKVGSEPAK DCLPAKPSEA TSDRSEGSSR DGQGSDENEE SSVVDYVEVT VGEEDAISDR SDSWSQAAAE GVSELAESDS DCVPAEAGQA
Target Information
Zinc-fingers and homeobox (ZHX) proteins are transcription factors that interact with the activation domain of the A subunit of nuclear factor-Y (NF-YA).
ZHX1–3 are ubiquitously expressed proteins in various tissues, acting as transcriptional repressors localized in the nucleus.
They contain two Cys(2)-His(2)-type zinc-finger motifs and five homeodomains (HDs), allowing homodimer and heterodimer formation, though dimerization is not required for repressor activity.
Hypermethylation-mediated silencing of ZHX2 is an epigenetic event involved in hepatocellular carcinoma (HCC).
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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