Thermo Fisher Scientific p130Cas Polyclonal Antibody
Thermo Fisher Scientific의 p130Cas Polyclonal Antibody는 Human, Mouse, Rat에 반응하며, WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. Recombinant fusion protein을 면역원으로 사용한 Rabbit IgG 폴리클로날 항체로, 액상 형태이며 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 495–612 of human BCAR1 (NP_055382.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.52 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914201 |
Product Specific Information
Positive test controls include HeLa and Mouse brain.
The target is typically localized in cell junctions, cytoplasm, and focal adhesions.
Immunogen sequence:
EPQEPLVQDL QAAVAAVQSA VHELLEFARS AVGNAAHTSD RALHAKLSRQ LQKMEDVHQT LVAHGQALDA GRGGSGATLE DLDRLVACSR AVPEDAKQLA SFLHGNASLL FRRTKATA
Target Information
p130Cas (Crk-associated substrate) is a cellular target of phosphorylation signals via v-Crk and v-Src oncoproteins.
It contains a Src homology (SH)-3 domain, multiple YXXP motifs, and a proline-rich region.
p130Cas is involved in biological processes such as:
- Cell adhesion and migration
- Growth factor stimulation
- Cytokine receptor engagement
- Bacterial infection
Physiological roles include cardiovascular development, actin filament assembly, and Src-induced cell transformation.
⚠ WARNING: This product contains mercury, a chemical known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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