Thermo Fisher Scientific V-ATPase Subunit A Polyclonal Antibody

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Product Specifications

Product Specific Information

The V-ATPase subunit A is a catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
This enzyme is a heteromultimeric complex composed of a peripheral catalytic V1 domain attached to an integral membrane V0 proton pore complex.
GenScript Rabbit Anti-V-ATPase Subunit A Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide and purified by immunoaffinity chromatography.

Target Information

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles.
V-ATPase-dependent organelle acidification is essential for processes such as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation.
The V1 domain contains the ATP catalytic site and consists of three A and three B subunits, two G subunits, plus C, D, E, F, and H subunits.
The V0 domain includes five different subunits: a, c, c′, c″, and d.
This encoded protein represents one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist.

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Not for use in diagnostic procedures.
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