Thermo Fisher Scientific CDK8 Polyclonal Antibody
CDK8 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC 및 IHC-P 실험에 적합합니다. 인간 단백질에 반응하며, 여러 종에서도 예측 반응성이 있습니다. 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC-P)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 414 and 464 of human cyclin-dependent kinase 8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Chicken, Turkey, Bovine, Dog, Horse, Rabbit, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, and Green anole.
Target Information
CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with Cyclin C. CDK8 belongs to the cyclin-dependent kinase (CDK) family, which are critical regulators of cell cycle progression. The prototype member, p34/Cdc2, and related protein Cdk2 function late in the cycle, while Cdk4 and Cdk6 are involved in G1 to S progression. Due to analogy with yeast Cdk8, it is proposed that human Cdk8–Cyclin C may interact with RNA polymerase, influencing transcription mechanisms leading to cell division.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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