Thermo Fisher Scientific EAF2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human EAF2 protein. Suitable for IHC and IHC (Paraffin) applications with 1:100–1:500 dilution. Antigen affinity purified, liquid form, stored at 4°C. Predicted cross-reactivity with primates including chimpanzee an...
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 150 and 200 of human ELL associated factor 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Predicted to react with Orangutan, Monkey, Gorilla, Chimpanzee, Crab-eating macaque, and White-tufted-ear marmoset based on 100% sequence identity
Target Information
EAF1 and EAF2 form a complex with ELL that targets the ternary elongation complex of Pol II, enhancing the rate of elongation. They are crucial for the stability of the NuA4 histone acetyltransferase complex, which activates transcription through acetylation of histones H4 and H2A. Both proteins are ubiquitously expressed and colocalize with ELL in Cajal bodies and nuclear speckles. EAF1 has a C-terminal region rich in acidic and serine residues, while EAF2 is an androgen-responsive gene acting as a potent apoptosis inducer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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