Thermo Fisher Scientific RuvBL2 Polyclonal Antibody
RuvBL2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, IHC 및 IHC(P) 실험에 적합합니다. Human과 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. TBS buffer에 0.1% BSA 포함, 4°C 보관.
- 카탈로그번호
- IHC00701x (2개 옵션)
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific RuvBL2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of Human RuvB-like 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Rat, Bovine, Dog, Horse, Rabbit, Guinea pig, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, and Crab-eating macaque
Target Information
RUVBL2 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity. It is a component of the NuA4 histone acetyltransferase complex, which activates transcription by acetylating nucleosomal histones H4 and H2A. This modification influences nucleosome–DNA interactions and promotes interactions with proteins that regulate transcription positively.
The NuA4 complex contributes to transcriptional programs associated with oncogene-mediated growth induction, tumor suppressor-mediated growth arrest, replicative senescence, apoptosis, and DNA repair. RUVBL2, together with RUVBL1 and EP400, provides ATPase and helicase activities to the complex and plays essential roles in oncogenic transformation by MYC and transcriptional regulation via the LEF1/TCF1-CTNNB1 complex. It may also inhibit ATF2 transcriptional activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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