Thermo Fisher Scientific 5HT1B Receptor (HTR1B) (extracellular) Polyclonal Antibody, Atto 488

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:80

Product Specifications

Product Specific Information

Reconstitution: 50 µL double distilled water (DDW), depending on the sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
The reconstituted solution can be stored at 4°C for up to 1 week.
For longer storage, aliquot and store at -20°C. Avoid multiple freeze/thaw cycles.
Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter involved in regulating diverse biological processes in the central and peripheral nervous systems, cardiovascular system, and gastrointestinal system.
Molecular cloning studies have identified multiple 5-HT1 subtypes, which are negatively coupled to adenylyl cyclase.
The 5-HT1B receptor (formerly 5-HT1DbR) is expressed in regions such as the substantia nigra, dorsal subiculum, globus pallidus, and superior colliculus.
In situ hybridization studies show high expression of 5-HT1BR mRNA in CA1 pyramidal cells of the hippocampus, Purkinje cells of the cerebellum, olfactory tubercle, and subthalamic nucleus, with lower levels in the caudate-putamen, cortical areas, thalamic, and hypothalamic nuclei.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.