Thermo Fisher Scientific Human IRF7 Synthetic Peptide

Thermo Fisher Scientific Human IRF7 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 14 amino acids near the center terminus of human IRF7.
PEP-0415 can be used as a blocking peptide with polyclonal antibody PA5-20281.

Target Information

Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms.
During infection, host-virus interactions signal downstream molecules such as transcription factors including IFN regulatory factor-3 (IRF3), which stimulate transcription of IFN-α/β genes.
IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes.
IRF7 plays a major role in the innate immune pathway, interacting with Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM, functioning as an intermediate in TLR4 and TLR9 signaling.
There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.